Anti-wall teichoic antibodies and conjugates

An antibody-antibiotic conjugate compound comprising an anti-wall teichoic acid (WTA) monoclonal antibody, wherein the anti-wall teichoic acid monoclonal antibody binds to Staphylococcus aureus, and covalently attached to a rifamycin-type antibiotic by a protease-cleavable, peptide linker, the antibody-antibiotic conjugate compound having Formula I:

• wherein:
• the dashed lines indicate an optional bond;
• R is H, C1-C12 alkyl, or C(O)CH3;
• R1 is OH;
• R2 is CH═N-(heterocyclyl), wherein the heterocyclyl is optionally substituted with one or more groups independently selected from C(O)CH3, C1-C12 alkyl, C1-C12 heteroaryl, C2-C20 heterocyclyl, C6-C20 aryl, and C3-C12 carbocyclyl;
• or R1 and R2 form a five- or six-membered fused heteroaryl or heterocyclyl, and optionally forming a spiro or fused six-membered heteroaryl, heterocyclyl, aryl, or carbocyclyl ring, wherein the spiro or fused six-membered heteroaryl, heterocyclyl, aryl, or carbocyclyl ring is optionally substituted H, F, Cl, Br, I, C1-C12 alkyl, or OH;
• L is the peptide linker attached to R2 or the fused heteroaryl or heterocyclyl formed by R1 and R2;
• Ab is the anti-wall teichoic acid monoclonal antibody;
• and
• p is an integer from 1 to 8.