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US 9,802,996 B2Granted
Glycosylated polypeptide and drug composition containing said polypeptide
AssigneeGlytech, Inc.
InventorsHirofumi Ochiai, Taiji Shimoda, Kazuhiro Fukae, Masatoshi Maeda, Keisuke Tazuru, Kenta Yoshida
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Abstract
[Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analog thereof being replaced by glycosylated amino acids.
Claims18
A polypeptide selected from the group consisting of:
- (A) a SRIF14 consisting of the amino acid sequence represented by SEQ ID NO:1;
- (B) a polypeptide having one amino acid deleted from, substituted with, or added to SRIF14, SRIF14 consisting of the amino acid sequence represented by SEQ ID NO:1;
- and
- (C) a polypeptide having 90% or more homology with SRIF14 consisting of the amino acid sequence represented by SEQ ID NO:1;
- wherein said polypeptide further comprises N amino acids at the N-terminal side, wherein N is an integer from 1 or more to 20 or less;
- and/or
- said polypeptide further comprises M amino acids at the C-terminal side, wherein M is an integer from 1 or more to 6 or less;
- wherein at least two amino acids of the N and/or M amino acids are substituted with a glycosylated amino acid, and the polypeptide has affinity towards somatostatin receptors.
5 more elements
A polypeptide selected from the group consisting of:
- (A) a SRIF28 consisting of the amino acid sequence of SEQ ID NO:2;
- (B) a polypeptide having one or two amino acids deleted from, substituted with, or added to SRIF28, SRIF28 consisting of the amino acid sequence of SEQ ID NO:2;
- (C) a polypeptide having 90% or more homology with SRIF28 consisting of the amino acid sequence of SEQ ID NO:2;
- (D) a polypeptide further comprising J amino acids at the N-terminal side of (A)-(C), wherein J is an integer from 1 or more to 6 or less;
- and
- (E) a polypeptide further comprising K amino acids at the C-terminal side of (A)-(C), wherein K is an integer from 1 or more to 6 or less;
- wherein at least two amino acids are substituted with a glycosylated amino acid, and the polypeptide has affinity towards somatostatin receptors.
4 more elements
Dependencies are inferred from the claim text.