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AssigneeThe Asan Foundation
InventorsJung-Min Koh, Ghi Su Kim, Seung Hun Lee, Young-Sun Lee, Beom-Jun Kim
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A pharmaceutical composition for preventing or treating a fracture or osteoporosis, includes, as an active ingredient, a gene selected from a group consisting of slit1, slit2, slit3, robo1, robo2 and vilse, or an expressed protein of the gene. A marker composition for predicting the risk of the occurrence of a fracture or osteoporosis includes the protein. A kit for predicting the risk of the occurrence of a fracture or osteoporosis includes an antibody that specifically binds to the protein. An information provision method for predicting the risk of the occurrence of a fracture or osteoporosis includes measuring the level of expression of the slit protein through an antigen-antibody binding reaction using an antibody that specifically binds to the protein. The slit3 may increase bone formation and decrease bone reabsorption in a cellular and animal model, and has a negative correlation with the incidence rate of osteoporosis.
A method for treating osteoporosis, the method comprising administering a therapeutically effective amount of a peptide of a leucine-rich repeat 2 (LRR2) domain of slit3 protein to a subject requiring a treatment of said osteoporosis,
A method for treating osteoporosis, the method comprising administering a therapeutically effective amount of a peptide of a leucine-rich repeat 2 (LRR2) domain of slit3 protein to a subject requiring a treatment of said osteoporosis,
Dependencies are inferred from the claim text.