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US 9,802,991 B2Granted
HSP20 inhibits amyloidogenesis and neurotoxicity
AssigneeThe Texas A&M University System
InventorsAllison Ficht, Theresa Good, Kenneth Carson, Sungmun Lee
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Abstract
The present inventions are compositions and methods of using at least a portion of an isolated and purified α-crystallin polypeptide that includes one or more β-pleated sheets and that prevents neurotoxicity and amyloidogenesis.
Claims6
A method of making a recombinant α-crystallin polypeptide comprising the steps of:
- culturing a host cell comprising a nucleic acid sequence encoding a fusion protein comprising the recombinant α-crystallin polypeptide under conditions wherein the host cell expresses the fusion protein, wherein the fusion protein has at least one of α-crystallin activity, attenuated neurotoxicity, and inhibits amyloidogenesis and wherein the fusion protein consists of SEQ ID NOS:
- 18-20.
Dependencies are inferred from the claim text.