Synthesis of diverse glycosylphosphatidylinositol glycans from Toxoplasma gondii and their application as vaccines and diagnostics

A compound of a formula (I):

• wherein
• R represents
• R1 is —OH and R4 is —OP(O)(OH)—O—X—NH2;
• X is selected from the group consisting of —CH2—, —C2H4—, —C3H6—, —C4H8—, —C5H10—, and —C6H12—;
• R2 represents —OP(O)(OR5)(OR6);
• R3 is selected from the group consisting of —H, —OH, —NH2, NHCOCH3, —NHCOCH2CH3, —NHCOCH2CH2CH3, and —N3;
• R5 and R6 are independently selected from the group consisting of —H, -L-SH, —(C2H4O)r—CH2—SH and —(C2H4O)r—C2H4—SH, with the proviso that R5 and R6 cannot both be —H, and one of R5 and R6 is hydrogen;
• L is a linking group;
• and
• r is an integer of from 1 to 40.