Crystalline forms of ferric maltol
AssigneeShield Tx (UK) Limited
InventorDavid Paul Childs
Life of this patent
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Abstract
There is provided polymorphs of ferric maltol. Such forms may be useful in the treatment of iron deficiency with or without anaemia, such as iron deficiency anaemia.
Claims28
Form II polymorph of ferric maltol characterized by a powder X-ray diffraction pattern comprising a characteristic crystalline peak expressed in degrees 2-theta at 8.3±0.25 degrees, and two or more further peaks expressed in degrees 2-theta selected from about 11.8, 12.5, 13.4, 14.5, 15.5, 15.6, 16.2, 16.7, 18.7, 19.2, 19.9, 20.6, 21.1, 22.8, 23.7, 24.6, 25.1, 25.7, 27.1, or 29.1±0.2, or ±0.1 such as about ±0.05 degrees.
Form I polymorph of ferric maltol characterized by a powder X-ray diffraction pattern comprising characteristic crystalline peaks expressed in degrees 2-theta at 15.6 and 22.5±0.25 degrees, and one or more further peaks expressed in degrees 2-theta selected from about 11.4, 12.8, 13.7, 16.9, 18.5, 19.6, 20.0, 20.7, 23.0, 23.8, 25.2 or 25.8±0.25 or ±0.2, or ±0.1 such as about ±0.05 degrees.
Form III polymorph of ferric maltol characterized by a powder X-ray diffraction pattern comprising a peak expressed in degrees 2-theta at 7.4±0.25 degrees, and two or more, three or more, four or more or five or more further peaks expressed in degrees 2-theta selected from about 9.3, 10.5, 11.6, 13.6, 14.0, 15.1, 17.0, 17.7, 18.2, 18.7, 20.5, 21.2, 22.1, 22.5, 23.6, 24.9, 27.4 and 30.6±0.2, or ±0.1 such as about ±0.05 degrees.
Form IV polymorph of ferric maltol characterized by a powder X-ray diffraction pattern comprising peaks expressed in degrees 2-theta at 9.5 and 14.5±0.2 degrees, and one or more further peaks expressed in degrees 2-theta selected from about 11.4, 12.8, 13.7, 15.5, 18.5, 19.9, 23.1, 25.0 and 25.8±0.2, or ±0.1 such as about ±0.05 degrees.
A composition comprising a mixture of Form I and Form II polymorphs.
Dependencies are inferred from the claim text.