Polymer coated particles and methods thereof
AssigneeThe University of North Carolina at Chapel Hill
InventorsSamuel K. Lai, Qi Yang
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Abstract
Embodiments of the presently-disclosed subject matter include a composition that comprises a particle, a plurality of surface functional groups on a surface of the particle, and a plurality of coating polymers bound to the surface functional groups and forming a coating on the particle that includes a density ratio of about 0.1 to about 20.0, the density ratio being equal to a Flory radius of the plurality of coating polymers divided by a distance between adjacent surface functional groups. Embodiments of the presently-disclosed subject matter also include methods for making the present compositions as well as methods for using the present compositions to deliver a bioactive agent and treat a subject in need thereof.
Claims17
A composition, comprising:
- a particle;
- a plurality of surface functional groups on a surface of the particle;
- and
- a plurality of coating polymers bound to the surface functional groups and forming a coating on the particle that includes a density ratio of about 1.0 to about 20.0, the density ratio being equal to a Flory radius of the plurality of coating polymers divided by a distance between adjacent surface functional groups;
- wherein the surface functional groups are selected from the group consisting of carboxyl, amine, aldehyde, acetal, thiol, acrylate, isocyanate, maleimide, hydroxyl, halogen, electrostatically charged functional groups, and combinations thereof.
A method for making a particle, comprising:
- providing a particle that includes surface functional groups on the surface of the particle;
- and
- contacting the surface functional groups of the particle with a plurality of coating polymers to form a coating on the particle that includes a density ratio of about 1.0 to about 20.0, the density ratio being equal to a Flory radius of the plurality of coating polymers divided by a distance between adjacent surface functional groups;
- wherein the surface functional groups are selected from the group consisting of carboxyl, amine, aldehyde, acetal, thiol, acrylate, isocyanate, maleimide, hydroxyl, halogen, electrostatically charged functional groups, and combinations thereof.
Dependencies are inferred from the claim text.