US 9,802,957 B2Granted

Processes of preparing a JAK1 inhibitor and new forms thereto

AssigneeIncyte Corporation

InventorsJiacheng Zhou, Shili Chen, Yongzhong Wu, Zhongjiang Jia, Yingrui Dai

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This invention relates to processes for preparing a JAK1 inhibitor having Formula Ia: as well as new forms of the inhibitor.

Dependent claims

A process of preparing a compound of Formula Ia:

comprising reacting a compound of Formula Ib:
with a strong base in the presence of a solvent component, wherein the compound of Formula Ib is present in a composition comprising the compound of Formula Ib and the compound of Formula Ia prior to said reacting of said compound of Formula Ib with said strong base.

Dependencies are inferred from the claim text.

C07D 495/14
In which the condensed system contains three hetero rings: ortho-condensed systems
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 5/14
Drugs for disorders of the endocrine system: of the thyroid hormones, e.g. T3, T4

From the US filing history. Foreign family members aren’t listed.

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