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US 9,802,945 B2Granted
Imidazopyridazine derivatives as modulators of the GABAA receptor activity
AssigneePfizer Inc.
InventorsRobert McKenzie Owen, David Cameron Pryde, Mifune Takeuchi, Christine Anne Louise Watson
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Abstract
The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
Claims9
A compound according to formula (I)
- wherein
- R1 is selected from H and (C1-C3)alkyl:
- R2 is selected from H and (C1-C3)alkyl and R3 is H;
- or
- R2 and R3 together are —CH2—;
- R4 is selected from H, F and OCH3;
- R5 is selected from H and F;
- and
- R6 is selected from (C2-C4)alkyl, (C3-C5)cycloalkyl and methyl-substituted (C3-C5)cycloalkyl,
- and wherein
- ring B is attached to ring A at any one of positions 3, 4 and 5;
- and
- R4 is attached to ring A at any one of positions 2, 3, 4 and 5, provided that R4 and ring B cannot both be attached to ring A at the same position,
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.