Back to results
US 9,802,901 B2Granted
Antibacterial 2H-indazole derivatives
AssigneeIdorsia Pharmaceuticals Ltd
InventorsJean-Christophe Gauvin, Azely Mirre, Etienne Ochala, Jean-Philippe Surivet
Life of this patent
Estimating the term…
Abstract
The invention relates to antibacterial compounds of formula I wherein R1 is H or halogen; R2 is alkynyloxy or the group M; R3 is H or halogen; M is one of the groups wherein A is a bond, CH2CH2, CH═CH or C≡C and R1A, R2A, R3A, R1B and R1C are as defined in claim 1; and salts thereof.
Claims16
A compound of formula I
- wherein
- R1 represents H or halogen;
- R2 represents (C3-C4)alkynyloxy or the group M;
- R3 represents H or halogen;
- M is one of the groups MA, MB, MC and MD represented hereafter
- wherein A represents a bond, CH2CH2, CH═CH or C≡C;
- R1A represents H or halogen;
- R2A represents H, (C1-C3)alkoxy or halogen;
- R3A represents H, (C1-C3)alkoxy, hydroxy(C1-C4)alkoxy, (C1-C3)alkoxy(C2-C3)alkoxy, dihydroxy(C3-C4)alkoxy, (C1-C3)thioalkoxy, trifluoromethoxy, amino, di(C1-C3)alkylamino, 2-hydroxyacetamido, hydroxy(C1-C4)alkyl, 1-aminocyclopropyl, 1-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 1,2-dihydroxyethyl, 3-hydroxyoxetan-3-yl, 3-(hydroxy(C1-C3)alkyl)oxetan-3-yl, 3-aminooxetan-3-yl, 3-(di(C1-C3)alkylamino)oxetan-3-yl, 3-hydroxythietan-3-yl, morpholin-4-yl(C2-C3)alkoxy, morpholin-4-yl-(C1-C2)alkyl, oxazol-2-yl or [1,2,3]triazol-2-yl;
- R1B represents 3-hydroxyoxetan-3-yl, 3-aminooxetan-3-yl, 3-hydroxythietan-3-yl, hydroxy(C1-C3)alkyl, dihydroxy(C2-C4)alkyl, amino(C1-C4)alkyl, (dimethylamino)methyl, 1-hydroxymethyl-cycloprop-1-yl, trans-2-(1,2-dihydroxyethyl)cycloprop-1-yl, 1-((phosphonooxy)methyl)cyclopropyl, 1-(((dimethylglycyl)oxy)methyl)cyclopropyl, 1-methyl-2-hydroxymethyl-cycloprop-1-yl, 2-(hydroxymethyl)-2-methylcyclopropyl, 1-aminocyclopropyl, trans-2-hydroxymethyl-cycloprop-1-yl, trans-2-aminomethyl-cycloprop-1-yl, 1-fluoro-2-(hydroxymethyl)cyclopropyl, 2-fluoro-2-(hydroxymethyl)cyclopropyl, 1-(hydroxymethyl)cyclobutyl, 3-hydroxy-oxetan-3-yl, 3-hydroxymethyl-oxetan-3-yl, 1-(2-hydroxyacetyl)azetidin-3-yl, 1-(2-aminoacetyl)azetidin-3-yl, 1-glycylazetidin-3-yl, 1-(2-amino-2-methylpropanoyl)azetidin-3-yl, 3-(2-aminoacetamido)cyclopentyl, trans-(cis-3,4-dihydroxy)-cyclopent-1-yl, 3-hydroxymethylbicyclo[1,1,1]pentan-1-yl, piperidin-4-yl, 1-(2-hydroxyacetyl)piperidin-4-yl, 1-(2-aminoacetyl)piperidin-4-yl, 4-hydroxytetrahydro-2H-pyran-4-yl, 5-aminotetrahydro-2H-pyran-2-yl, (1s,3r)-(1-hydroxy-3-(hydroxymethyl)cyclobutyl)methyl or 3-hydroxyoxetan-3-ylmethyl;
- and
- R1C represents 1-hydroxymethyl-cycloprop-1-yl, trans-2-(1,2-dihydroxyethyl)cycloprop-1-yl, 1-methyl-2-hydroxymethyl-cycloprop-1-yl, 2-(hydroxymethyl)-2-methylcyclopropyl, 1-aminocyclopropyl, trans-2-hydroxymethyl-cycloprop-1-yl, 1-fluoro-2-(hydroxymethyl)cyclopropyl or 2-fluoro-2-(hydroxymethyl)cyclopropyl;
- or a salt of the compound.
10 more elements
Dependencies are inferred from the claim text.