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US 9,802,898 B2Granted
Phenyl and tertbutylacetic acid substituted pyridinones having anti-HIV effects
AssigneeViiV Healthcare UK Limited
InventorsBrian Alvin Johns, Emile Johann Velthuisen
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Abstract
Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds.
Claims10
A compound of Formula I:
- wherein:
- R1 is phenyl optionally substituted by one to four substituents selected from C1-3alkyl, halogen, or —CH2CH2CH2O— wherein this group is bonded to adjacent carbon atoms on the phenyl to form a ring;
- L is a bond, C1-3alkylene, —SO2—, —SO2CH2—, —NHSO2—, —NHSO2CH2—, —C(O)—, —C(O)NH—, —C(O)NHCH2—, —C(O)OCH2—, —C(O)C(O)—, —CH2C(O)—, C3-7heteroaryl, or —C3-7heteroarylNH—, wherein each heteroaryl comprises one to three heteroatoms selected from S, N, and O;
- R2 is H, cyclohexyl, or phenyl wherein said cyclohexyl and phenyl are optionally substituted by one to three substituents selected from C1-3alkyl and halogen
- R3 is H or —NHSO2R4 wherein R4 is C1-8alkyl and wherein said alkyl can include cycloalkyl portions.
2 more elements
Dependencies are inferred from the claim text.