Back to results
US 9,802,893 B2Granted
Methods of producing molindone and its salts
AssigneeSupernus Pharmaceuticals, Inc.
InventorsMartin Hanbauer, Zarghun Nazir, Peter Hildebrand, Attilia Figini, Likan Liang, Tiziano Fumagalli
Life of this patent
Estimating the term…
Abstract
The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
Claims18
A process for preparing molindone (SUMO-3), comprising:
- (a) forming formyl SUMO-2 by reacting 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole (SUMO-2) with a base and ethyl formate;
- (b) reacting formyl SUMO-2 with morpholine to form an enamine of formyl SUMO-2;
- and
- (c) reducing the enamine to form molindone
1 more element
A process for preparing molindone (SUMO-3), comprising reacting SUMO-2 with bismorpholinomethane to form molindone:
Dependencies are inferred from the claim text.