Back to results
US 9,802,887 B2Granted
Process for the preparation of intermediates useful for the manufacture NEP inhibitors
AssigneeNovartis AG
InventorsDavid Hook, Bernhard Riss, Jianguang Zhou, Yunzhong Li, Erhard Bappert
Life of this patent
Estimating the term…
Abstract
The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
Claims3
An isolated (Z)-isomer of a compound according to formula (5) having no (E)-isomer present, or salt thereof,
- wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R is hydrogen or a C1-C6-alkyl residue.
Dependencies are inferred from the claim text.