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US 9,802,374 B2Granted
Biopolymer sensor and method of manufacturing the same
AssigneeTufts University
InventorsDavid L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb, Irene Georgakoudi
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Abstract
A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
Claims22
A biopolymer sensor device, comprising:
- a solidified silk fibroin film, wherein the solidified silk fibroin film is characterized by beta-sheet secondary structure;
- at least one biologically active material, which is embedded in the solidified silk fibroin film and/or coated on a surface of the solidified silk fibroin film;
- wherein the solidified silk fibroin film is or comprises an optically active component selected from the group consisting of a lens, a microlens array, a nanolens array, an optical grating, a pattern generator, a beam diffuser, a beam homogenizer, and a beam reshaper,
- wherein the optically active component and biologically active material are selected and arranged so that the biopolymer sensor device exhibits an optical signature when interrogated by incident electromagnetic radiation, and
- wherein the optical signature is altered when the biopolymer sensor device is exposed to at least one substance and/or environmental feature.
2 more elements
Dependencies are inferred from the claim text.