Manufacturing method of two-chamber type combined container-syringe

A manufacturing method of two-chamber type combined container-syringe, comprising:

• a dissolving solution filling process of preparing a dissolving solution-filled cartridge by inserting an end stopper into an inner side of a cartridge which extends along an axis line and has a cylindrical shape, filling a dissolving solution onto the end stopper inside the cartridge, and inserting a middle stopper into a bypass portion positioned on an upper part of the dissolving solution in the cartridge so that the bypass portion is in a communication state;
• a vacuum plugging process of eliminating air bubbles from the dissolving solution in the dissolving solution-filled cartridge and sealing the dissolving solution with the middle stopper after the dissolving solution filling process, and
• a steam sterilization process of sterilizing the dissolving solution-filled cartridge after the vacuum plugging process,
• wherein the vacuum plugging process includes
• a first cooling processing of cooling the inside of a vacuum plugging equipment in which the dissolving solution-filled cartridge is disposed to a cooling temperature at which the dissolving solution is not frozen,
• a first decompression processing of decreasing pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing, and
• a middle stopper pushing processing of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing,
• wherein the steam sterilization process is performed in a state where a plurality of cartridges are stowed inside a steel tub which is formed of stainless steel, an upper part of which is open, and which has a box shape, is disposed at an angle such that the axis line of the cartridge is inclined relative to a vertical direction.