Flowable matrix compositions and methods
AssigneeAlloSource
InventorsReginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
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Abstract
Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
Claims67
A soft tissue matrix composition for use in a patient treatment, the composition consisting of a cryofractured human soft tissue material having a mechanically disrupted extracellular matrix collagen or macrostructure and a partially disrupted collagen microfibrillar architecture, wherein the cryofractured tissue material is in a naturally hydrated state, the hydration comprising the natural interstitial water of the cryofractured soft tissue material that is present prior to cryofractionation.
A soft tissue matrix composition for use in a patient treatment, the composition consisting of a cryofractured and triturated human soft tissue material having a mechanically disrupted extracellular matrix collagen or macrostructure and a partially disrupted collagen microfibrillar architecture, wherein the cryofractured and triturated tissue material is in a naturally hydrated state, the hydration comprising the natural interstitial water of the cryofractured and triturated human soft tissue material that is present prior to cryofractionation and trituration.
A soft tissue matrix composition for use in a patient treatment prepared by a method consisting of:
- providing a human soft tissue material;
- processing the human soft tissue material to mechanically disrupt the extracellular matrix collagen or macrostructure and a partially disrupt the collagen microfibrillar architecture by a process selected from the group consisting of:
- (i) cryofracturing the human soft tissue material;
- (ii) cryofracturing and washing the human soft tissue material;
- (iii) cryofracturing and triturating the human soft tissue material;
- and
- (iv) cryofracturing, triturating, and washing the human soft tissue material,
- wherein the processed tissue material is in a naturally hydrated state, the hydration comprising a substantial amount of the natural interstitial water of the human soft tissue material.
Dependencies are inferred from the claim text.