Mussel-inspired bioactive surface coating composition generating silica nanoparticles
AssigneePostech Academy-Industry Foundation
InventorsHyung Joon Cha, Yun Kee Jo, Hogyun Cheong, Changsup Kim, Bong-Hyuk Choi
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Abstract
The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.
Claims7
A method for promoting osteoblast attachment, proliferation, spreading and differentiation including the steps of
- providing a substrate;
- coating the substrate with a substrate surface coating composition comprising a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein;
- and
- providing osteoblast on the substrate surface coating composition so as to promote the attachment, proliferation, spreading and differentiation of the osteoblast.
Dependencies are inferred from the claim text.