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US 9,801,959 B2Granted
Phospholipid composition and microbubbles and emulsions formed using same
AssigneeMicrovascuar Therapeutics LLC
InventorsEvan C. Unger, Daniel C. Evans
Life of this patent
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Abstract
A composition for stabilizing a fluorocarbon emulsion. That composition includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid.
Claims12
A composition for stabilizing an octafluoropropane emulsion, comprising:
- octafluoropropane;
- phosphatidylcholine;
- phosphatidylethanolamine-polyethylene glycol (PEG);
- and
- dipalmitoylphosphatidylethanolamine (DPPE),
- wherein
- the composition comprises no dipalmitoylphosphatidic acid (DPPA),
- the composition has a pH between 6.2 and 6.8, and
- the dipalmitoylphosphatidylethanolamine (DPPE) is at a concentration between about 5 and about 20 mole percent of the composition.
6 more elements
A lyophilized composition, comprising:
- octafluoropropane;
- phosphatidylcholine;
- phosphatidylethanolamine-polyethylene glycol (PEG);
- and
- dipalmitoylphosphatidylethanolamine (DPPE),
- wherein
- the composition comprises no dipalmitoylphosphatidic acid (DPPA),
- the composition has a pH between 6.2 and 6.8, and
- the dipalmitoylphosphatidylethanolamine (DPPE) is at a concentration between about 5 and about 20 mole percent of the composition.
6 more elements
A composition of an octafluoropropane emulsion, comprising:
- octafluoropropane;
- phosphatidylcholine;
- phosphatidylethanolamine-polyethylene glycol (PEG);
- and
- dipalmitoylphosphatidylethanolamine (DPPE),
- wherein
- the composition comprises no dipalmitoylphosphatidic acid (DPPA),
- the composition has a pH between 6.2 and 6.8, and
- the dipalmitoylphosphatidylethanolamine (DPPE) is at a concentration between about 5 and about 20 mole percent of the composition.
6 more elements
Dependencies are inferred from the claim text.