US 9,801,958 B2 · Polymer nanoparticle composite and composition for MRI imaging including same

Abstract

The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.

Claims18

Dependent claims

A polymer nanoparticle composite comprising:

a block copolymer comprising a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment;
and MnCaP;
wherein the anionic polymer chain segment is a polypeptide having an anionic group on a side chain of the polypeptide;
and
wherein the non-charged hydrophilic polymer chain segment is selected from the group consisting of polyethylene glycol, poly(2-methyl-2-oxazolineT poly(2-ethyl-2-oxazolineT poly(2-isoprot>yl-2-oxazoline), polyacrylamide, polymethacrylamide, polyvinyl alcohol, polvthvdroxyethyl acrylate) and polv(hvdroxy ethyl methacrylate).

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/913,903Filed 22 Aug 2014

Priority

JP 2013-17386623 Aug 2013

Published

US 2016/0206759 A121 Jul 2016

Granted

31 Oct 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 49/1872
The nanoparticle having a magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid: coated or functionalised with a…
A61K 49/128
Linear polymers, e.g. dextran, inulin, PEG: comprising multiple complex or complex-forming groups, being either part of the linear polymeric…
A61K 49/1818
Characterised by a special physical form, e.g. emulsions, microcapsules, liposomes: particles, e.g. uncoated or non-functionalised microparticles…
C08K 3/32
Use of inorganic substances as compounding ingredients: phosphorus-containing compounds

Polymer nanoparticle composite and composition for MRI imaging including same

Life of this patent

Polymer nanoparticle composite and composition for MRI imaging including same

Life of this patent

Abstract

Claims18