Lipid-based nanoparticles
OwnerAnanth Annapragada, Jason L. Eriksen +3inventors
InventorsAnanth Annapragada, Jason L. Eriksen, Eric A. Tanifum, Indrani Dasgupta, Stephen C. Cook
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Abstract
Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.
Claims12
A liposomal composition, comprising:
- a membrane, comprising:
- a first phospholipid;
- cholesterol;
- a second phospholipid, the second phospholipid being derivatized with a polymer;
- a third phospholipid, the third phospholipid being a phospholipid-polymer-aromatic compound conjugate,
- the phospholipid-polymer-aromatic compound conjugate being represented by:
- wherein n is about 10 to about 100;
- and
- a nonradioactive magnetic resonance imaging (MM) contrast enhancing agent at least one of encapsulated by or bound to the membrane.
A method for imaging amyloid deposits in a patient, the method comprising:
- introducing into the patient a detectable quantity of a liposomal composition comprising:
- a membrane, comprising:
- a first phospholipid;
- cholesterol;
- a second phospholipid, the second phospholipid derivatized with a polymer;
- and
- a third phospholipid, the third phospholipid being a phospholipid-polymer-aromatic compound conjugate represented by:
- wherein n is about 10 to about 100;
- and
- a nonradioactive magnetic resonance imaging (MRI) contrast enhancing agent at least one of encapsulated by or bound to the membrane;
- allowing sufficient time for the liposomal composition to be associated with one or more amyloid deposits;
- and
- detecting the liposomal composition associated with the one or more amyloid deposits.
A liposomal composition for capturing images of amyloid deposits on a patient's brain, the liposomal composition comprising:
- DPPC;
- cholesterol;
- DSPE-mPEG-2000;
- and
- wherein:
- n is about 10 to about 100;
- and
- Gd-DTPA-BSA.
Dependencies are inferred from the claim text.