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US 9,801,954 B2Granted
Lipid substitution on aminoglycoside based polymers: plasmid delivery, anticancer drug delivery and transgene expression
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsKaushal Rege, Bhavani Miryala, Thrimoorthy Potta
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Abstract
A method to form a lipid-containing aminoglycoside-based polymer, where the method includes reacting an aminoglycoside with a diepoxide to form an aminoglycoside-based polymeric material, and then reacting the aminoglycoside-based polymeric material with an acyl chloride to form the lipid-containing aminoglycoside-based polymer.
Claims16
A method to form an aminoglycoside based polymer, comprising:
- reacting an aminoglycoside having a structure:
- wherein R1 is an aminoglycoside monomer, with a diepoxide having a structure:
- wherein R2 is a backbone of said diepoxide, to form an aminoglycoside-based polymeric material having a structure:
- wherein n is between about 3 and about 10.
1 more element
A lipid-conjugated polymer, coprising:
- wherein R1 is an aminoglycoside monomer, R2 is a backbone of a diepoxide, and R3 is an alkyl group comprising C6, C14, or C18.
A method to form an aminoglycoside based polymer, comprising:
- reacting an aminoglycoside with a diepoxide in a solvent system of DMSO to form an aminoglycoside-based polymeric material.
Dependencies are inferred from the claim text.