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US 9,801,941 B2Granted
Phenylephrine-containing liquid formulations
AssigneeWyeth
InventorsAmanda Alley, William Bubnis, Stephanie Shield
Life of this patent
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Abstract
An oral, aqueous-based, liquid pharmaceutical composition is provided. The composition comprises up to about 45% glycerin and up to about 10% sorbitol wherein the glycerin to sorbitol ratio is about 2:1 to 10:1.
Claims17
An aqueous oral pharmaceutical solution comprising:
- a) 0.05% w/v phenylephrine;
- b) 0.01% to 0.4% w/v sucralose;
- c) 18% to 30% w/v glycerin;
- and
- d) 3% to 10% w/v sorbitol;
- wherein the glycerin to sorbitol ratio is about 2:1 to about 5:1;
- wherein the aqueous oral pharmaceutical solution contains no conventional sugar sweeteners;
- wherein the solution contains no suspension embodiments selected from the group consisting of xanthan, microcrystalline cellulose, and combinations thereof;
- and
- wherein the solution is substantially free of phenylephrine degradants as measured under conditions of 40° C. and 75% relative humidity for 1 month.
7 more elements
Dependencies are inferred from the claim text.