Composition for inducing proliferation or accumulation of regulatory T cells
AssigneeThe University of Tokyo
InventorsKenya Honda, Koji Atarashi, Kikuji Itoh, Takeshi Tanoue
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Abstract
It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.
Claims44
A pharmaceutical composition, comprising a purified bacterial mixture of at least two live bacterial strains belonging to Clostridium clusters IV and/or XIVa, wherein the bacterial mixture induces proliferation and/or accumulation of regulatory T cells, wherein the bacterial cells are isolated from a human, wherein the pharmaceutical composition is formulated for delivery to the intestine, and wherein the composition does not include Bacteroides, Lactobacillus, or Bifidobacterium.
A pharmaceutical composition, comprising a purified bacterial mixture of at least three live bacterial strains belonging to Clostridium clusters IV and/or XIVa, wherein the bacterial mixture induces proliferation and/or accumulation of regulatory T cells, wherein the bacterial strains are isolated from a human, and wherein the pharmaceutical composition is formulated for delivery to the intestine, and wherein the pharmaceutical composition does not include Bacteroides.
A pharmaceutical composition, comprising a purified bacterial mixture of at least three live bacterial strains belonging to Clostridium clusters IV and/or XIVa, wherein the bacterial mixture induces proliferation and/or accumulation of regulatory T cells, wherein the bacterial cells are isolated from a human, wherein the pharmaceutical composition is formulated for delivery to the intestine, and wherein the pharmaceutical composition does not include Lactobacillus.
A pharmaceutical composition, comprising a purified bacterial mixture of at least three live bacterial strains belonging to Clostridium clusters IV and/or XIVa, wherein the bacterial mixture induces proliferation and/or accumulation of regulatory T cells, wherein the bacterial cells are isolated from a human, wherein the pharmaceutical composition is formulated for delivery to the intestine, and wherein the pharmaceutical composition does not include Bifidobacterium.
Dependencies are inferred from the claim text.