Immune tolerance inducer
AssigneeNapaJen Pharma, Inc.
InventorsKo Rii, Kazuo Sakurai, Masakazu Kobayashi, Hironori Ando, Sadaharu Higuchi, Shiro Takahara
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Abstract
An object of the present invention is to provide a drug and a method for effectively inducing donor-specific immune tolerance in a recipient in transplantation therapy. A complex of an siRNA for a costimulatory factor and schizophyllan is delivered to a Dectin-1 expressing cell which specifically recognizes schizophyllan to regulate the function of the Dectin-1 expressing cell, and therefore can induce immunosuppression effect as well as induce immune tolerance effectively.
Claims5
A method for inducing immune tolerance in transplantation therapy, comprising a step of intravenously administering a nucleic acid-polysaccharide complex, the complex consisting of an siRNA which inhibits CD40 gene expression, to which polydeoxyadenine is added, and schizophyllan to an animal in need of immune tolerance for a donor cell, organ or tissue.
Dependencies are inferred from the claim text.