Compositions and methods of treating cancer
AssigneesUniversity of Iowa Research Foundation, The Regents of the University of Michigan
InventorsDouglas R. Spitz, Michael K. Schultz, Kyle Kloepping, Yueming Zhu, Nukhet Aykin-Burns, Max S. Wicha
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Abstract
The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.
Claims16
A method for treating lung cancer in a mammal, comprising administering to the mammal a pharmaceutical composition comprising a decyl-TPP agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria, an inhibitor of hydroperoxide metabolism, and a pharmaceutically acceptable diluent or carrier.
A method for inducing cellular apoptosis or clonogenic cell killing of a cancerous lung cell, comprising contacting the cancerous lung cell with an effective toxicity-inducing amount a composition comprising a decyl-TPP agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria, an inhibitor of hydroperoxide metabolism, and a pharmaceutically acceptable diluent or carrier.
A method for increasing the anticancer effects of a lung cancer therapy on a cancerous lung cell in a mammal, comprising contacting the cancerous cell with an effective amount of the composition comprising a decyl-TPP agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria, an inhibitor of hydroperoxide metabolism, and a pharmaceutically acceptable diluent or carrier, and contacting prior to administering an additional cancer therapy.
A method for inducing oxidative stress in a lung cancer cell in a mammal in need of such treatment comprising administering to the mammal an effective amount of the composition comprising a decyl-TPP agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria, an inhibitor of hydroperoxide metabolism, and a pharmaceutically acceptable diluent or carrier.
Dependencies are inferred from the claim text.