Film-coated and/or granulated calcium-containing compounds and use therof in pharmaceutical compositions
AssigneeTakeda GmbH
InventorJan Yngvar Piene
Life of this patent
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Abstract
Calcium-containing compounds have been at least partly film-coated and/or granulated with a water-soluble substance and a water-soluble polymeric substance and use of such coated compounds in pharmaceutical compositions. The at least partly film-coated and/or granulated calcium-containing compounds have proved suitable for the preparation of tablets having a very high load of elemental calcium and a conveniently small size. A drug load of about 96% or more is obtained in tablets of the invention that have sufficient mechanical and organoleptic properties.
Claims17
A granulated calcium-containing compound, wherein the calcium-containing compound is in the form of particles and/or crystals that have been granulated with a granulating composition containing i) xylitol, and ii) one or more polymeric substances selected from the group consisting of povidones and copovidones, and mixtures thereof, wherein at least a part of the surface of the calcium-containing compound is provided with a film that is formed by the granulating composition, and wherein the xylitol constitutes from about 2% to about 20% of the total weight of the granulated calcium-containing compound, and the one or more polymeric substances constitutes from about 0.09% to about 10% of the total weight of the granulated calcium-containing compound.
Dependencies are inferred from the claim text.