Artificial tear emulsion
AssigneeHorus Pharma
InventorsClaude Claret, Martine Claret, Carole Gard, Nicola Lamprecht-Weissenborn
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Abstract
The present invention relates to an oil-in-water emulsion comprising at least one mucomimetic polymer, at least one lipid of phospholipid type, at least one lipid other than the phospholipid, at least one stabilizing polymer, and a hydrophilic liquid, to an emulsion comprising an aqueous phase that contains at least one stabilizing polymer and at least one mucomimetic polymer, and an oily phase that contains at least one lipid of phospholipid type and a lipid other than the phospholipid, to a medicament comprising one of these emulsions, and to the use of one of these emulsions as an agent for restoring and/or replacing the lachrimal film or as a carrier for an active compound.
Claims25
An eye lotion being a stable oil-in-water emulsion, without surfactants other than phospholipid, having an osmolarity of 110 to 180 mOsm/1 said oil-in-water emulsion comprising:
- at least one mucomimetic polymer selected from glycosaminoglycans and hyaluronic acids,
- at least one phospholipid,
- at least one lipid other than the phospholipid, which is a triglyceride whose three hydroxyl groups are esterified by fatty acids comprising from 8 to 12 carbon atoms,
- at least one stabilizing polymer selected from cellulose polymers,
- water, and
- a salt selected from potassium chloride, sodium chloride or potassium and/or sodium carbonate.
An eye lotion being a stable oil-in-water emulsion, without surfactants other than phospholipid, having an osmolarity of 110 to 180 mOsm/1, and comprising:
- 0.01 to 5% by weight of at least one mucomimetic polymer, said mucomimetic polymer being selected from glycosaminoglycans and hyaluronic acids,
- 0.01 to 3% by weight of at least one phospholipid, said phospholipid being selected from phosphoacylglycerides, phosphosphingolipids, phosphonosphingolipids, phosphoglycolipids and phosphosaccharolipids,
- 0.01 to 5% by weight of at least one lipid other than the phospholipid, said lipid other than the phospholipid which is a triglyceride whose three hydroxyl groups are esterified by fatty acids comprising from 8 to 12 carbon atoms,
- 0.01% to 5% by weight of at least one stabilizing polymer, said stabilizing polymer being selected from cellulose polymers,
- from 0 to 10 ppm of preservatives and/or EDTA, and
- a salt selected from potassium chloride, sodium chloride or potassium and/or sodium carbonate
- water.
Dependencies are inferred from the claim text.