US 9,801,895 B1 · Cream formulation with amphotericin B and oil in water useful for topical application to mucous tissue and skin against diseases produced by leishmaniasis

Abstract

The cream formulation of the present invention is a topical cream made with antimycotic (amphotericin B) and a mixture of excipients where the water present in the formulation smoothes inflamed tissue. The cream has a particular application for the treatment of cutaneous leishmaniasis and mucosal leishmaniasis in humans and animals. The topical application avoids the risks of toxicity and the gastrointestinal hassles of pills treatments. It has greater acceptability from patient and does not require of valuations before, during or after treatment to check toxicity levels of the liver, kidney and heart.

Claims8

Dependent claims

A cream formulation for topical application to a patient's mucous tissue and/or skin against diseases produced by leishmaniasis, said formulation consisting of:

Amphotericin B as a pharmaceutical active ingredient from 0.3% to 3.0% by weight;
sodium methylparaben in 0.10% by weight;
sodium propylparaben in 0.02% by weight;
monobasic sodium phosphate in 0.96% by weight;
cetyl alcohol in 5.0% by weight;
light mineral oil in 4.0% by weight;
mixture of:
Cetyl alcohol, Glyceryl Stearate, PEG-75 Stearate, Ceteth-20 and Steareth-20 in 2.90% by weight;
white petrolatum in 10.0% by weight;
glycerol monostearate in 0.7% by weight;
and
water from 76.02% to 73.32% by weight.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/952,351Filed 26 Jul 2013

Granted

31 Oct 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61K 31/7048
Compounds having saccharide radicals and heterocyclic rings: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin,…
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/006
Mouth and digestive tract, i.e. intraoral and peroral administration: oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or…
A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Cream formulation with amphotericin B and oil in water useful for topical application to mucous tissue and skin against diseases produced by leishmaniasis

Life of this patent

Cream formulation with amphotericin B and oil in water useful for topical application to mucous tissue and skin against diseases produced by leishmaniasis

Life of this patent

Abstract

Claims8