Method of treatment for prostate cancer with androgen receptor antagonists and glucocorticoid receptor antagonists
AssigneeThe University of Chicago
InventorsRussell Z. Szmulewitz, Suzanne D. Conzen
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Abstract
Methods are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.
Claims11
A method of treating prostate cancer in a subject comprising administering to said subject therapeutically effective amounts of an androgen receptor (AR) antagonist, a glucocorticoid receptor (GR) antagonist, and a second prostate cancer therapy selected from the group consisting of chemical therapy, radiotherapy, cryotherapy, immunotherapy, and surgery.
Dependencies are inferred from the claim text.