5-substituted isoindoline compounds

A method of treating or managing a disease or disorder which comprises administering to a patient in need of such treatment or management a therapeutically effective amount of a compound of formula (I):

• or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein:
• X is CH2 or C═O;
• Z is:
• (CH2)m, wherein m is 0 or 1;
• or NH;
• R1 is halogen or (C1-C6)alkyl, itself optionally substituted with one or more halogen;
• and
• R2 is hydrogen;
• halogen;
• or (C1-C6)alkyl, itself optionally substituted with one or more halogen;
• and
• wherein the disease or disorder is cancer or a disorder associated with angiogenesis.