Back to results
US 9,801,867 B2Granted
Processes of making and crystalline forms of a MDM2 inhibitor
AssigneeAmgen Inc.
InventorsMatthew Bio, Sebastien Caille, Brian Cochran, Yuanqing Fang, Brian M. Fox, Brian S. Lucas, Lawrence R. McGee, Filisaty Vounatsos, Sean H. Wiedemann, Sarah Wortman
Life of this patent
Estimating the term…
Abstract
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Claims30
A process of making
- the process comprising reacting
- to form
A process of making
- the process comprising reacting
- with 1,4-diazabicyclo[2.2.2]octane (DABCO) to form
A process of making
- the process comprising reacting
- with an acid to form
Dependencies are inferred from the claim text.