Antimicrobial substituted thiazoles and methods of use
AssigneePurdue Research Foundation
InventorsMark Stanley Cushman, Mohamed Seleem, Abdelrahman S Mayhoub
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Abstract
Disclosed are compositions having activity against MRSA and/or VRSA, and methods of using the compositions to treat microbial infections.
Claims10
A method of treating a bacterial infection in a subject comprising administering to the subject a pharmaceutical composition in an amount effective to treat the infection, the pharmaceutical composition comprising a compound having the chemical structure:
- wherein Z consists of aminoguanidine, guanidine, or hydrazinecarboximidamide Y consists of cyclohexyl, cyclohexenyl or naphthyl, and R consists of methyl, wherein the compound has antibacterial activity, and wherein the compound does not substantially disrupt bacterial cell membranes.
A method of treating a bacterial infection in a subject comprising administering to the subject a pharmaceutical composition in an amount effective to treat the infection, the pharmaceutical composistion comprising a compound having the chemical structure:
A method of treating a bacterial infection in a subject comprising administering to the subject a pharmaceutical composition in an amount effective to treat the infection, the pharmaceutical composistion comprising a compound having the chemical structure:
Dependencies are inferred from the claim text.