Nanocrystalline solid dispersion compositions and process of preparation thereof

A method for preparing discrete particles of a nanocrystalline solid dispersion comprising:

• a) dissolving at least one active ingredient in at least one first solvent to produce solution A;
• b) dissolving at least one crystallization inducer excipient in at least one second solvent to produce solution B;
• c) mixing of said solution A and solution B in a proportion to produce solution C;
• d) drying of solution C to evaporate the first and second solvents and to form the said discrete particles of said nanocrystalline solid dispersion, wherein the solvent evaporation and formation of discrete particles from Solution C is carried out by spray drying, vacuum drying, or solvent evaporation, and wherein drying is carried out at a temperature above the glass transition temperature of active ingredient or the glass transition temperature of active ingredient in combination with crystallization inducer(s) optionally along with pharmaceutically acceptable excipient(s) and below the melting point of the active ingredient in presence of crystallization inducer(s) optionally along with pharmaceutically acceptable excipient(s);
• wherein said discrete particles of nanocrystalline solid dispersion are in powder form;
• wherein said discrete particle comprises crystals of said active ingredient(s) in a matrix of the said crystallization inducer(s) and/or coexisting with crystals of crystallization inducer(s), optionally along with pharmaceutically acceptable excipient(s) which further may be soluble completely or partially.