Ultrapure tetrahydrocannabinol-11-oic acids
AssigneeCorbus Pharmaceuticals, Inc.
InventorMark Tepper
Life of this patent
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Abstract
This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of inflammation, pain, and fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, idiopathic pulmonary fibrosis, Dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarring-wound healing abnormalities, post-operative adhesions, and reactive fibrosis.
Claims18
A method of treating a subject having an inflammatory disease the method comprising administering to the subject a pharmaceutical composition comprising one or more cannabinoids, wherein said one or more cannabinoids comprise at least 98% (w/w) (6aR, 10aR)-3-(1′, 1′-dimethylheptyI)-Δ8-tetrahydro-cannabinol-9-carboxylic acid (Ajulemic Acid), or a pharmaceutically acceptable salt thereof, and wherein no significant antinociception is observed in a hot plate test of mice following oral administration to the mice of 10 mg/kg of said one or more cannabinoids.
Dependencies are inferred from the claim text.