Prevention of rosacea inflammation
AssigneeThe Regents of the University of California
InventorsRichard L. Gallo, Anna Di Nardo, Yumiko Muto
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Abstract
The disclosure demonstrates the role of mast cell stabilizers in treating rosacea. The disclosure also shows the role of mast cells, cathelicidin, serine protease and/or vitamin D3 in rosacea pathology and the use of antagonists and inhibitors thereof to treat rosacea.
Claims3
A method of treating rosacea comprising contacting a subject having rosacea with a topical composition consisting of a mast cell stabilizer and any combination of agents selected from the group consisting of (i) an agent that inhibits a neuropeptide, (ii) a serine protease inhibitor, and (iii) a vitamin D3 antagonist, wherein the mast cell stabilizer is selected from the group consisting of lodoxamide, nedocromil, cromolyn, pemirolast and pharmaceutical salts of any of the foregoing.
Dependencies are inferred from the claim text.