Using palmitoylethanolamide in combination with opioids
AssigneeEpitech Group S.r.l.
InventorsFrancesco Della Valle, Maria Federica Della Valle, Lorenzo Di Cesare Manelli, Carla Ghelardini
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Abstract
Described herein are pharmaceutical compositions for human or animal use containing N-palmitoylethanolamide as an analgesic in combination with opioids. In particular, the compositions include palmitoylethanolamide in non-micronized form, in micronized form (PEA-m), in ultra-micronized form (PEAum) or mixtures thereof, for use in humans or animals in combination with an opioid in the treatment of pain conditions, wherein said palmitoylethanolamide is administered separately, sequentially, or in combination with said opioid.
Claims6
A method of delaying the onset of opioid tolerance in a patient under treatment of pain conditions with morphine, comprising administering an effective amount of palmitoylethanolamide ultra-micronized form (PEAum), wherein said palmitoylethanolamide is administered daily to the patient starting from 1 day before the start of treatment with morphine, or carrying out a 10-day pre-treatment before the start of treatment with morphine.
Dependencies are inferred from the claim text.