Accordion pill comprising levodopa for an improved treatment of Parkinson's Disease symptoms

A method for the treatment of symptoms of Parkinson's disease in a subject in need thereof over a 24 hour period, comprising administering to said subject an accordion pill comprising levodopa,

• wherein the accordion pill comprising levodopa is administered to the subject in a twice daily administration regimen of two doses in a day, as a first dose of the day and as a second dose of the same day, with an interval of about 8 to about 10 hours between the first dose of the day and the second dose of the same day, and with an interval of about 14 to about 16 hours between the second dose of the day and the first dose of the following consecutive day over a period of more than one week;
• and
• wherein the accordion pill comprising levodopa is a multilayered gastroretentive dosage form, folded into a capsule in undulated form, which unfolds upon contact with gastric fluids.