Pouch-like structure with paracrine activity and method for its preparation
AssigneeGeorg-August-Universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin
InventorsWolfram Hubertus Zimmermann, PohLoong Soong
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Abstract
A pouch-like structure useful for mechanically preventing distension and/or resisting dilation of the heart and for supporting the hearts function by controllable and paracrine support of a failing heart in a mammal, is composed at least partly of engineered tissue with genetically engineered cells other than cardiac myocytes. The genetically engineered cells contain a gene encoding a paracrine factor which is under control of an inducible promoter system or a heterologous promoter system. The preparation of the pouch-like structure may be used for therapeutic, disease modelling, and drug development applications.
Claims8
A pouch-like structure suitable for enclosing at least a part of a heart of a mammal, comprising:
- an engineered tissue comprising genetically engineered cells that contain a transgene encoding a paracrine factor operably linked to an inducible promoter or a heterologous promoter, wherein the genetically engineered cells are cells other than cardiac myocytes and are selected from the group consisting of fibroblasts, smooth muscle cells, endothelial cells, mesenchymal stem cells, cardiac stem cells, pericytes, leucocytes, precursor cells, and pluripotent stem cells.
Dependencies are inferred from the claim text.