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US 9,801,807 B2Granted
Topical formulations for increasing the dermal concentration of hyaluronic acid
AssigneeShamroc, Inc.
InventorsMark W. Trumbore, Drake D. Stimson, Ronald M. Gurge
Life of this patent
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Abstract
Described herein are methods and compositions for increasing dermal concentrations of glycosaminoglycans (GAG), including hyaluronic acid. Exemplary methods involve a one-step protocol and a three-step protocol. Either method can be used over a 90-day treatment period.
Claims12
A method of increasing the hyaluronic acid concentration in an area of skin of a subject, comprising the steps of:
- applying to the area of skin a therapeutically-effective amount of a first formulation, wherein the first formulation comprises
- water, in a quantity from about 25% to about 65% by weight;
- denatured alcohol, in a quantity from about 12% to about 36% by weight;
- a plurality of keratolytic agents in a quantity from about 6% to about 18% by weight;
- and
- a plurality of moisturizers, emollients, humectants, or skin soothing agents in a quantity from about 5% to about 15% by weight;
- applying to the area of skin a therapeutically-effective amount of a second formulation, wherein the second formulation comprises
- a) water;
- b) glycerin;
- c) dimethicone;
- d) pentylene glycol;
- e) water, purified;
- f) dimethicone/divinyl-dimethicone/silsesquioxane crosspolymer;
- g) Helianthus annuus (sunflower) seed oil;
- h) panthenol;
- i) ethylhexyl stearate;
- j) dimethiconol;
- k) tetrahexyldecyl ascorbate;
- l) betaine;
- m) tocopherol;
- n) acrylates/c10-30 alkyl acrylate crosspolymer;
- o) Rubus occidentalis (black raspberry) seed oil;
- p) Vaccinium macrocarpon (cranberry) seed oil;
- q) Punica granatum (pomegranate) seed oil;
- r) urea;
- s) Rubus idaeus (raspberry) seed oil;
- t) superoxide dismutase;
- u) allantoin;
- v) chlorphenesin;
- w) sodium hydroxide;
- x) potassium lactate;
- y) sodium lauroyl lactylate;
- z) xanthan gum;
- aa) sodium benzoate;
- bb) ethyl hexylglycerin;
- cc) sodium isostearate;
- dd) sodium hyaluronate crosspolymer;
- ee) polyglyceryl-4 diisostearate/polyhydroxystearate/sebacate;
- ff) potassium sorbate;
- gg) hydrolyzed hyaluronic acid;
- hh) zinc citrate;
- ii) (ii) disodium EDTA;
- jj) sodium butyroyl/formoyl hyaluronate;
- kk) hydrolyzed sclerotium gum;
- ll) polyglutamic acid;
- mm) caprylyl glycol;
- nn) lecithin;
- oo) tetradecyl aminobutyroylvalyl-aminobutyric urea trifluoro-acetate;
- pp) palmitoyl tripeptide-5;
- qq) ceramide 3;
- rr) phytosphingosine;
- ss) cholesterol;
- tt) ceramide 6 II;
- uu) methylisothiazolinone;
- vv)Micrococcus lysate;
- ww) Arabidopsis thaliana extract;
- xx) plankton extract;
- yy) carbomer;
- zz) palmitoyl dipeptide-5diaminohydroxybutyrate;
- aaa) palmitoyl dipeptide-5diamino-butyroyl hydroxy threonine;
- bbb) magnesium chloride;
- ccc) acetyl octapeptide-3;
- ddd) pentapeptide-3;
- eee) ceramide 1;
- and
- fff) fragrance;
- and
- applying to the area of skin a therapeutically-effective amount of a third formulation, wherein the third formulation comprises
- water, in about 25% to about 75% by weight;
- a plurality of moisturizers, emollients, humectants, or skin soothing agents in a quantity from about 15% to about 45% by weight;
- and
- a plurality of plant extracts or fruit seed oils.
69 more elements
Dependencies are inferred from the claim text.