Nicotine delivery product and method for producing it
AssigneeFertin Pharma A/S
InventorCarsten Andersen
Life of this patent
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Abstract
A nicotine delivery product comprising the reaction product of a nicotine/cation exchange resin complex and an organic polyol; and a method for preparing it comprising (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and (b) removing water from the mixture to produce said nicotine delivery product. The nicotine delivery product has a nicotine release rate of at least 80% over a 10 minute period. It is particularly suited for use in smoking substitution devices delivering nicotine such as chewing gum, patches, lozenges, melting tablets and tablets for chewing.
Claims18
A method of preparing a nicotine delivery product, said method comprising:
- (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and
- (b) removing water from the mixture to produce said nicotine delivery product having a nicotine release rate of at least 80% over a 10 minute period.
A method of preparing a nicotine delivery product, said method comprising:
- (a) mixing an aqueous solution of nicotine with a cation exchange resin thereby forming a nicotine/cation exchange resin complex in aqueous suspension,
- (b) admixing with said complex of step (a) in aqueous suspension an organic polyol or an aqueous solution thereof to form an aqueous slurry of nicotine/cation exchange resin complex incorporating polyol, and
- (c) removing water from said slurry to produce said nicotine delivery product having a nicotine release rate of at least 80% over a 10 minute period.
A method of preparing a nicotine delivery product having a nicotine release rate of at least 80% over a 10 minute period, said method comprising:
- (a) mixing an aqueous solution of nicotine with a cation exchange resin selected from the group consisting of:
- (i) a methacrylic, weakly acidic type of resin containing carboxylic functional groups,
- (ii) a polystyrene, strongly acidic type of resin containing sulfonic functional groups, and
- (iii) a polystyrene, intermediate acidic type of resin containing phosphonic functional groups;
- thereby forming a nicotine/cation exchange resin complex,
- (b) admixing with said complex of step (a) an organic polyol or an aqueous solution thereof to form an aqueous slurry of nicotine/cation exchange resin complex incorporating polyol;
- and
- (c) removing water from said slurry to produce said nicotine delivery product having a nicotine release rate of at least 80% over a 10 minute period.
Dependencies are inferred from the claim text.