US 9,795,311 B2 · Method for intraluminal pressure detection for diverticular disease

Abstract

A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

Claims20

Dependent claims

A method for estimating a peak pressure within the colon of a subject, the method comprising:

providing a pressure detection tablet comprising a capsule, wherein the capsule comprises:
a water-soluble and non-metabolizable dye encapsulated within an inner coating, wherein the inner coating is configured to rupture at a pressure equal to or higher than a pressure threshold, and
an outer coating surrounding the capsule, wherein the dye is absorbed by the colon and excreted by the kidneys in urine upon rupture of the inner coating;
orally administering the pressure detection tablet to the subject;
observing a color of the subject's urine after a test period;
and
estimating the peak pressure within the colon of the subject during the test period based on the color of the subject's urine.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/355,616Filed 18 Nov 2016 · division

Priority

IN 2359/DEL/201420 Aug 2014

Published

US 2017/0065192 A19 Mar 2017

Granted

24 Oct 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

A61B 5/03
Measuring for diagnostic purposes ; Identification of persons: measuring fluid pressure within the body other than blood pressure, e.g. cerebral…
A61B 5/4255
Evaluating particular parts, e.g. particular organs: intestines, colon or appendix
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/2072
Pills, tablets, discs, rods: characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially…

Method for intraluminal pressure detection for diverticular disease

Life of this patent

Method for intraluminal pressure detection for diverticular disease

Life of this patent

Abstract

Claims20