Multinozzle emitter arrays for ultrahigh-throughput nanoelectrospray mass spectrometry
AssigneeThe Regents of the University of California
InventorsDaojing Wang, Pan Mao, Hung-Ta Wang, Peidong Yang
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Abstract
The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.
Claims14
A device comprising:
- a structure, the structure being circularly-shaped, a plurality of emitters defined on a circumference of the structure, a plurality of access holes defined in a first planar surface of the structure, a plurality of channels defined in the structure, each of the plurality of access holes being in fluid communication with one of the plurality of channels, each of the plurality of channels being in fluid communication with one of the plurality of emitters, a first emitter being defined by a top surface, a bottom surface, a left surface, a right surface, and an end surface, either the top surface and the bottom surface or the left surface and the right surface of the first emitter being sharpened to taper to the end surface;
- and
- a plurality of nozzles disposed in the end surface of each of the plurality of emitters, each of the plurality of nozzles protruding from the end surface of each of the plurality of emitters, the plurality of nozzles being in fluid communication with the channel of the emitter, and each of the plurality of nozzles including an end from which the nozzle is operable to emit a liquid.
Dependencies are inferred from the claim text.