Method for diagnosing a molecular phenotype of a patient suffering from an illness accompanied by chronic inflammation
AssigneeSterna Biologicals GmbH & Co. KG
InventorsAgnieszka Turowska, Joachim Bille
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Abstract
Chronic inflammation is an increasing medical problem area of high socioeconomic significance. The invention relates to a method and a kit for diagnosing a molecular phenotype of a patient suffering from an illness accompanied by chronic inflammation, and to a medicament for treating such a patient. To that end, the gene expression of GATA-3 and/or Tbet in a biological isolate of the patient is measured and used for association with a molecular phenotype of the illness.
Claims6
A method for diagnosing and treating chronic inflammation in a patient suffering from an illness associated with chronic inflammation, by identifying a molecular phenotype of the patient wherein the molecular phenotype is selected from the group consisting of the subgroups “Th2 high”, and “Th2 low” and the gene expression of Th2 cell-specific transcription factor (GATA-3) and/or the Th1 cell-specific transcription factor (Tbet) is measured in a biological isolate of the patient and used for the assignment to a molecular phenotype of the illness wherein the expression level of GATA-3 and/or Tbet is determined via the protein or mRNA quantity, and wherein the protein quantity is quantitatively determined by an immunoassay and wherein a therapeutic agent effective for specifically inhibiting GATA-3 or Tbet expression according to the identified molecular phenotype is administered to the patient.
Dependencies are inferred from the claim text.