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US 9,791,448 B2Granted
Breast cancer assay
AssigneeNottingham Trent University
InventorsAdam Linley, Stephanie Mcardle, Chungui Lu, Robert Rees, Stephen Yan Tat Chan, Tarek Mohamed Ahmed Abdel-Fateh
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Abstract
The application describes a method of screening for breast cancer by testing fro the amount of HAGE (Helicase antigen) in a sample of breast tissue. Methods of prognosis of samples of breast cancer tumours are also provided. HAGE+ ER− (estrogen receptor-) cancers are indicated as being amenable to chemotherapy. Methods of treating breast cancers with HAGE-specific CTA antigen or HAGE-specific antibodies are also provided.
Claims6
A method of screening for and treating aggressive breast cancer in a subject comprising
- a) obtaining a sample of breast tumour tissue from a subject;
- b) detecting whether the sample is HAGE+ wherein helicase antigen HAGE+ is defined as the presence of cytoplasmic and/or nuclear staining with an anti-HAGE antibody in more than 10% of malignant cells;
- c) diagnosing the subject as having an aggressive breast cancer or having an increased probability that the breast cancer is aggressive when the sample is HAGE+;
- and
- d) administering an effective amount of chemotherapy to a subject diagnosed as having an aggressive breast cancer or having an increased probability that the breast cancer is aggressive.
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