Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
AssigneeMeMed Diagnostics Ltd.
InventorsEran Eden, Kfir Oved
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Abstract
The present invention provides methods of detecting infection using biomarkers. The methods disclosed herein include measuring the expression level of one or more polypeptide determinants in which the alteration of the expression level indicates infection of the patient. The methods provided herein are for distinguishing between bacterial infection, mixed infection, and/or viral infection. The methods disclosed herein may also further comprise measuring one or more non-polypeptide determinants. The present disclosure also provides methods for selection of a treatment regimen for the subject based on whether the subject is identified as having a bacterial or mixed infection, or a viral infection.
Claims11
A method of treating a subject in need thereof, the method comprising:
- (a) measuring the level of MX dynamin-like GTPase 1 (MX1) and the level of C-reactive protein (CRP) in a sample of the subject;
- (b) classifying whether the subject has a bacterial infection using a hyperplane having been calculated by combining the measurements of said CRP and said MX1 of a training population;
- and
- (c) treating the subject classified as having said bacterial infection with an antibiotic agent, thereby treating the subject.
Dependencies are inferred from the claim text.