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US 9,791,440 B2Granted
Assays for antimicrobial activity and applications thereof
AssigneePresident and Fellows of Harvard College
InventorsMark J. Cartwright, Nazita Gamini, Donald E. Ingber, Martin Rottman, Michael Super, Julie A. Tomolonis, Karen A. Sinclair
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Abstract
The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
Claims5
A method of diagnosing a microbial infection in a subject, the method comprising:
- (i) assaying a biological sample from a subject for the presence of MAMPs with a PRR-based assay;
- and
- (ii) comparing the detectable signal level of MAMPs obtained from (i) to the level of MAMPs in a non-infected subject;
- and
- (iii) identifying the subject to be likely infected with at least one microbe if the detectable signal level of MAMPs is higher than the level of MAMPs in a non-infected subject;
- or
- identifying the subject to be unlikely infected with microbes if the detectable signal level is not higher than the level of MAMPs in a non-infected subject.
4 more elements
Dependencies are inferred from the claim text.