Micro-fluidic surface plasmon resonance chip

A micro-fluidic chip comprising:

• a chip base having a plurality of flow cells defined therein and a plurality of micro-fluidic channels defined therein, each micro-fluidic channel being fluidly connected to a respective flow cell to deliver fluid to and from the flow cell, the chip base further having a plurality of fluid input ports fluidly connected to a respective micro-fluidic channel to deliver fluid thereto, and the chip base further having a plurality of fluid output ports fluidly connected to a respective micro-fluidic channel to remove fluid therefrom;
• a plurality of hemispherical or curved lenses, each lens having an apex and a base, the apex of each lens being positioned within a respective flow cell;
• and
• a securing portion affixed to the chip base such that the lenses are sandwiched between the chip base and the securing portion, the securing portion having a plurality of circular cavities defined therein in a surface adjacent the chip base, each circular cavity to receive the base of a respective lens, the securing portion further having a plurality of separate light input and output channels defined therein in a surface opposite the chip base, each light channel on a base side of its respective lens and at least partially open to a respective circular cavity such that each light input channel allows light into the respective circular cavity and the base of a respective lens and such that each light output channel allows light out of the respective circular cavity and the base of the respective lens.