Method for purification of 225AC from irradiated 226RA-targets
AssigneeActinium Pharmaceuticals, Inc.
InventorsJosue Manuel Moreno Bermudez, Andreas Turler, Richard Henkelmann, Eva Kabai, Ernst Huenges
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Abstract
The present invention describes a method for purification of 225Ac from irradiated 226Ra-targets provided on a support comprising a leaching treatment of the 225Ra-targets for leaching essentially for the entirety of 223Ac and 226Ra with nitric or hydrochloric acid, followed by a first extraction chromatography for separating 225Ac from 226Ra and other Ra-isotops and a second extraction chromotography for separating 225Ac from 210Po and 210Pb. The finally purified 225Ac can be used to prepare compositions useful for pharmaceutical purposes.
Claims22
A method for purification of 225Ac from irradiated 226Ra-targets provided on a support, comprising the following steps:
- a) leaching 225Ac and 226Ra from one or more 226Ra-targets with a nitric acid solvent in a refluxing/distillation arrangement to generate one or more 225Ac and 226Ra containing extracts, wherein said nitric acid solvent has a concentration range of about 0.001 M to about 2 M;
- b) concentrating the 225Ac and 226Ra containing extracts, wherein the concentrating results in a 225Ac and 226Ra containing extract having a concentration of about 1.5 M to about 10 M of HNO3;
- c) separating 225Ac from 226Ra and other Ra isotopes by means of at least one first extraction chromatography with a solid support material having a first extractant system coated thereon, comprising at least one compound in accordance with general formula IA,
- wherein in formula IA:
- R1a, R2a, R3a, R4a independently is octyl or 2-ethylhexyl;
- d) allowing the 226Ra to flow through and then eluting 225Ac retained on the solid support with nitric acid having a concentration between about 0.01M and about 0.3M or with hydrochloric acid having a concentration between about 0.05M and about 1M;
- e) separating 225Ac from 210Po and 210Pb by means of at least one second extraction chromatography with a solid support material having a second extractant system coated thereon, comprising at least one compound in accordance with general formula III in at least one compound in accordance with general formula IV,
- wherein in formula III:
- R8 and R9 independently is H, C1-C6 alkyl, or t-butyl;
- and
- wherein in formula IV:
- R10 is C4 to C12 alkyl;
- f) using 2M HCl as mobile phase;
- and
- g) recovering 225Ac as a flow-through separately from 210Po and 210Pb, which are retained on the solid support.
A method for purification of 225Ac from irradiated 226Ra-targets provided on a support, comprising the following steps:
- a) leaching 225Ac and 226Ra from one or more 226Ra-targets with a nitric acid solvent in a refluxing/distillation arrangement to generate one or more 225Ac and 226Ra containing extracts, wherein said nitric acid solvent has a concentration range of about 0.001 M to about 2 M;
- b) concentrating the 225Ac and 226Ra containing extracts, wherein the concentrating results in a 225Ac and 226Ra containing extract having a concentration of about 1.5 M to about 10 M of HNO3;
- c) separating 225Ac from 226Ra and other Ra isotopes by means of at least one first extraction chromatography with a solid support material having a first extractant system coated thereon, comprising at least one compound in accordance with general formula IB,
- d) allowing the 226Ra to flow through and then eluting 225Ac retained on the solid support with nitric acid having a concentration between about 0.02 M and about 0.1 M;
- e) separating 225Ac from 210Po and 210Pb by means of at least one second extraction chromatography with a solid support material having a second extractant system coated thereon, comprising at least one compound in accordance with general formula III in at least one compound in accordance with general formula IV,
- wherein in formula III:
- R8 and R9 independently is H, C1-C6 alkyl, or t-butyl;
- and
- wherein in formula IV:
- R10 is C4 to C12 alkyl;
- f) using 2M HCl as mobile phase;
- and
- g) recovering 225Ac as a flow-through separately from 210Po and 210Pb which are retained on the solid support.
Dependencies are inferred from the claim text.