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US 9,790,558 B2Granted
Method and probe set for detecting cancer
AssigneesMayo Foundation for Medical Education and Research, Abbott Molecular Inc.
InventorsKevin C. Halling, Robert B. Jenkins, Walter King, Irina A. Sokolova, Steven A. Seelig
Life of this patent
Estimating the term…
Abstract
Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.
Claims8
A method of screening for cancer in a subject comprising:
- (a) obtaining a kit comprising a set of chromosomal probes consisting of a centromeric probe to chromosome 3 labelled with fluorophore that can be visualized with a red or green filter, a centromeric probe to chromosome 7 labelled with fluorophore that can be visualized with a red or green filter, and a centromeric probe to chromosome 17 labelled with fluorophore that can be visualized with an aqua filter;
- or consisting of a centromeric probe to chromosome 3 labelled with fluorophore that can be visualized with a red or green filter, a centromeric probe to chromosome 7 labelled with fluorophore that can be visualized with a red or green filter, and a centromeric probe to chromosome 17 labelled with fluorophore that can be visualized with an aqua filter, and a locus specific probe to chromosome 9 labelled with fluorophore that can be visualized with a yellow filter;
- and
- (b) detecting the presence or absence of aneusomic cells in a biological sample by hybridizing said set of chromosomal probes of said kit to cells obtained from said biological sample from said subject and examining the hybridization pattern of said set of chromosomal probes;
- wherein the presence of aneusomic cells in said biological sample is indicative of cancer in said subject.
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Dependencies are inferred from the claim text.