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US 9,790,551 B2Granted
Use of TRPC6 mRNA levels in peripheral blood cells for early detection/diagnosis of senile dementia
AssigneeAging Wise Biotechnology, Inc.
InventorsYizheng Wang, Junfeng Wang, Rui Lu
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Abstract
The invention relates to the use of TRPC6 mRNA levels in peripheral blood cells for the early detection/diagnosis of senile dementia. Specifically, the present invention provides a classic transient receptor potential channel 6 (TRPC6) gene or protein thereof and the use of same in preparing a reagent or test kit for detecting or diagnosing Alzheimer's disease. The present invention further relates to a polypeptide used to prepare a medicament that treats AD, and relates to a composition of said polypeptide.
Claims4
A detection method for early auxiliary diagnosis of Alzheimer's disease (AD), comprising:
- (a) extracting mRNAs in peripheral blood or peripheral blood cells obtained from a subject, which is a mammal;
- (b) generating cDNAs from the mRNAs obtained in (a);
- (c) measuring the level of nucleic acids encoding TRPC6 in the cDNAs obtained in (b) by performing an amplification assay which comprises contacting the cDNAs with a pair of primers consisting of SEQ ID NO:
- 1 and SEQ ID NO:
- 2;
- and
- (d) determining whether the subject is at risk for AD, wherein an elevated level of TRPC6 measured by step (c) as relative to the level of TRPC6 in a non-AD control population suggests a higher AD risk or susceptibility of said subject than the non-AD control population.
4 more elements
Dependencies are inferred from the claim text.